Medicine, Nursing, Pharmacology

Below is a list of projects for this category:

CAPRISA 004 Phase IIb Trial to Assess the Safety and Effectiveness of the Vaginal Microbicide 1% Tenofovir Gel for the Prevention of HIV Infection in women in South Africa
The CAPRISA 004 study is being conducted to establish whether the vaginal use of tenofovir gel is safe and whether it can prevent male-to-female sexual transmission of HIV. Specifically, researchers conducting CAPRISA 004 are evaluating the safety and effectiveness of tenofovir in comparison to a placebo gel (a matched gel with no active ingredient) in sexually active women at risk for human immunodeficiency virus (HIV) infection in South Africa. This is the first effectiveness study of an antiretroviral drug formulated as a microbicide gel for prevention of HIV. It is also the first microbicide trial where the consortium of partners is being led by a developing country institution - the Centre for the AIDS Programme of Research in South Africa (CAPRISA) based at the University of KwaZulu-Natal in Durban, South Africa. website: http://www.caprisa.org/Projects/microbicides.html

CAPRISA 104: Microbicide Case Control Study to evaluate behavioural patterns of risk and gel use in a phase 2b trial.
The study is being conducted in South Africa in collaboration with the Centre for the AIDS Programme of Research in South Africa (CAPRISA). The major goals of the project are to evaluate behavioral variability in HIV infection outcomes among participants in a Phase IIb microbicide trial in South Africa (CAPRISA 004). The design integrates qualitative and quantitative data collection strategies.

Oral Tenofovir for HIV Prevention
The objective of this grant is to evaluate the safety and preliminary effectiveness of oral tenofovir as pre-exposure prophylaxis against HIV-infection in high-risk populations. The study was completed in Ghana, Cameroon, and is being redesigned for Malawi in Africa.